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Best AI models that run on Quad RTX Pro 6000 Blackwell build (384 GB)

Workstation-form datacenter, four cards deep.

NVIDIA · workstation / 4U pedestal
Quad RTX Pro 6000 Blackwell build (384 GB)
384 GB 372 GB usable 1792 GB/s $38k
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What models fit this build

Quad RTX Pro 6000 Blackwell build (384 GB) has 372 GB of usable memory. Here's which open-weights model sizes fit at each quant, at ~8K context with an FP8 KV cache.

Largest comfortable fit: ~670B MoE at Q2 (~282 GB).

Model size Q2Q4Q5Q8
7–8B Fits Fits Fits Fits
13–14B Fits Fits Fits Fits
30–32B Fits Fits Fits Fits
70–72B Fits Fits Fits Fits
~120B MoE Fits Fits Fits Fits
~235B MoE Fits Fits Fits Fits
~670B MoE Fits Won't fit Won't fit Won't fit
1T+ MoE Won't fit Won't fit Won't fit Won't fit

✓ = the weights + FP8 KV cache fit within this build's usable memory at ~8K context. Longer context needs more — size any model in the picker →

Our picks for this build

Sourced from the State of Local AI snapshot — the model + quant + backend we'd actually deploy on this hardware today, with the recipe in the setup guide below.

Recommended

Qwen 3.5 397B-A17B (MoE)

397 B · 17B active Apache 2.0 🤗

Feb 17 2026 flagship. 397B / 17B-active hybrid GDN-MoE — was the open-weights coding king pre-Qwen 3.6 (SWE-V 76.4, LCB v6 83.6, AIME26 91.3). First Qwen open-weights with native vision. ~25 tok/s on a 256 GB M3 Ultra with offload.

≥262 GB Q4 188 t/s
  • HLE37.6%
  • TB252.5%
  • SWE-Pro50.9%
  • SWE-Ver76.4%

Coding: From mid-Feb through April 2026 this was the local-coding king — daily-driver in Cline, Roo Code, Aider, Open-Claude, Continue via llama-server or vLLM. Now decisively dethroned by Qwen 3.6 27B (SWE-Ver 77.2 vs 76.4) and Qwen 3.6 35B-A3B on every coding eval per Qwen's own comparison table. Still a heavyweight generalist.

Agent: First 200B+ open MoE genuinely usable for autonomous loops — TAU2-Bench 86.7, TB2 52.5, MCP-Mark 46.1. Pair with 256 GB M3 Ultra (Q4 ~25 tok/s) or a multi-H100 box. Open-Claude users have largely moved to GLM-5.1 / Kimi K2.6 / DeepSeek V4 for new long-horizon work.

Also runs well

MiniMax M2.7 230B-A10B (MoE)

230 B · 10B active MiniMax Model License 🤗

Apr 12 2026. 230 B / 10 B active MoE — agent-tuned with native multi-agent ("Agent Teams"). 57% Terminal-Bench 2.0, 56% SWE-Bench Pro — strongest sub-300 B open-weights agent.

≥150 GB Q4 319 t/s
  • TB245.1%
  • SWE-Pro56.2%
  • SWE-Ver78.0%

Coding: Self-evolving 'Agent Teams' play — runs 100+ scaffold-optimization rounds. r/LocalLLaMA pricing-conscious folks like it via official MiniMax API; local at 230B with 10B active is fast on a Pro 6000. Not in the top 8 OpenRouter coding by volume — adoption still niche.

Agent: Strongest sub-300B open-weights agent-tuned model. Multi-agent native — designed for orchestrator loops. Reliable in 30-min Open-Claude sessions; ceiling around 1-2 hours. Notable harness gap: vendor's 57.0 TB2 vs tbench.ai's 45.1 — community runs do not match self-report.

Setup guide for Quad RTX Pro 6000 Blackwell build (384 GB)

Every known recipe for running a model on this build — sourced from the State of Local AI 2026-07-05 snapshot (2026-07-05). Pick the one that matches your model + quant, then follow the linked original write-up.

Recipes for Quad RTX Pro 6000 Blackwell build (384 GB)
ModelDecode tok/sPrompt processingRecipeRuns
qwen3-5-397b-a17b-moe@ AWQ-INT4 (QuantTrio) on SGLang+MTP~152@ 4Klocal-inference-lab/rtx6kpro wiki (Qwen3.5-397B single-batch decode)
qwen3-5-397b-a17b-moe@ NVFP4 (nvidia checkpoint) on vLLM+MTP~130@ 4Klocal-inference-lab/rtx6kpro wiki (Qwen3.5-397B MTP scaling table, concurrency=1)
minimax-m2-7-230b-moe@ MiniMax-M2.5-FP8 on vLLM~81@ 20Klocal-inference-lab/rtx6kpro wiki (MiniMax-M2.5 single-stream table)

Want to compare this against other builds? Open the live picker (Q2 / Q4 / Q5 / Q8 toggles) or see best build by budget.

See all recipes

Every open-weights model that fits, ranked by composite score

Composite blends benchmark averages (60 %) with editorial 0-5 ratings (40 %). Closed-frontier references mix into the ranking and stay amber-tinted.

Modeltg/sppTTFT @ 100KHLETB2SWE-ProSWE-VerAiderLCBGPQAMMLU-ProScore
Qwen 3 235B-A22B (MoE)235 B · 22 B active · moe🤗
145 t/s9,000 pp16 s70.7%81.1%84.4%4964
Qwen 3 Next 80B-A3B (MoE)80 B · 3 B active · moe🤗
19,000 pp7.5 s78.4%77.2%82.7%4920
52 t/s5,700 pp23 s77.6%4689
Qwen 3.5 9B9 B · dense🤗
284 t/s47,000 pp3.0 s65.6%81.7%82.5%4623
GLM-4.5-Air 106B (MoE)106 B · 12 B active · moe🤗
19,000 pp7.5 s57.6%4488
DeepSeek V4-Flash 284B (MoE)284 B · 13 B active · moe🤗
245 t/s9,000 pp16 s29.4%56.9%52.6%79.0%91.6%88.1%86.4%4379
58 t/s9,000 pp16 s26.7%71.9%89.0%87.0%86.8%4372
DiffusionGemma 26B-A4B26 B · 4 B active · diffusion-moe🤗
450 t/s13,000 pp10 s69.1%73.2%77.6%4358
Mistral Small 4 119B-A6B (MoE)119 B · 6 B active · moe🤗
19,000 pp7.5 s71.2%4301
Qwen 3.5 397B-A17B (MoE)397 B · 17 B active · moe🤗
188 t/s9,000 pp16 s37.6%52.5%50.9%76.4%83.6%88.4%87.8%4300
150 t/s13,000 pp10 s24.0%59.3%53.5%77.2%83.9%87.8%86.2%4280
Qwen 3 32B32 B · dense🤗
127 t/s13,000 pp10 s65.7%65.5%4278
95 t/s5,700 pp23 s57.5%65.2%84.0%4171
Phi-4 14B14 B · dense🤗
230 t/s27,000 pp5.0 s56.1%70.4%4160
Qwen 3.6 35B-A3B (MoE)35 B · 3 B active · moe🤗
450 t/s13,000 pp10 s21.4%51.5%49.5%73.4%80.4%86.0%85.2%4084
Qwen 3.5 122B-A10B (MoE)122 B · 10 B active · moe🤗
19,000 pp7.5 s25.3%49.4%72.0%78.9%86.6%86.7%4021
Tencent Hy3 295B-A21B (MoE)295 B · 21 B active · moe🤗
152 t/s9,000 pp16 s25.5%54.4%57.9%78.0%90.4%87.4%3971
Llama 4 Maverick 400B-A17B (MoE)400 B · 17 B active · moe🤗
188 t/s9,000 pp16 s43.4%69.8%80.5%3905
19,000 pp7.5 s18.3%31.0%60.5%81.2%79.2%83.7%3839
Llama 3.1 405B405 B · dense🤗
44 t/s9,000 pp16 s51.1%73.4%3762
268 t/s27,000 pp5.0 s5.2%72.0%78.8%77.2%3759
131 t/s13,000 pp10 s19.5%42.9%35.7%52.0%80.0%84.3%85.2%3697
Xiaomi MiMo V2.5 310B-A15B (MoE)310 B · 15 B active · moe🤗
213 t/s9,000 pp16 s65.8%56.1%3690
MiniMax M2.7 230B-A10B (MoE)230 B · 10 B active · moe🤗
319 t/s9,000 pp16 s45.1%56.2%78.0%3620
MiniMax M3 428B-A23B (MoE)428 B · 23 B active · moe🤗
139 t/s9,000 pp16 s59.0%3579
GPT-OSS 120B120 B · 5 B active · moe🤗
19,000 pp7.5 s18.5%18.7%16.2%62.4%87.8%80.9%90.0%3573
169 t/s13,000 pp10 s45.3%66.0%3361
Gemma 3 27B27 B · dense🤗
150 t/s13,000 pp10 s42.4%67.5%3321
Llama 4 Scout 109B-A17B (MoE)109 B · 17 B active · moe🤗
19,000 pp7.5 s32.8%57.2%74.3%3315
54 t/s5,700 pp23 s32.6%72.2%3174
Gemma 4 26B-A4B (MoE)26 B · 4 B active · moe🤗
450 t/s13,000 pp10 s8.7%34.2%13.8%17.4%77.1%82.3%82.6%3060
Qwen 3 Coder 30B-A3B (MoE)30 B · 3 B active · moe🤗
450 t/s13,000 pp10 s50.3%3042
Llama 3.3 70B70 B · dense🤗
95 t/s5,700 pp23 s28.8%50.5%68.9%2990
Llama 3.1 8B8 B · dense🤗
320 t/s47,000 pp3.0 s34.6%49.0%2527
Qwen 3 8B8 B · dense🤗
320 t/s47,000 pp3.0 s2.8%47.0%65.5%2325
19,000 pp7.5 s44
Cohere Command A+ 218B-A25B (MoE)218 B · 25 B active · moe🤗
128 t/s9,000 pp16 s39
Gemini 3.1 ProGoogle DeepMind · closed125 t/s2.1 min44.7%80.2%54.2%80.6%91.7%94.3%91.0%
ChatGPT 5.5OpenAI · closed61 t/s1.6 min52.2%82.0%58.6%88.7%88.0%93.6%
Claude Sonnet 5Anthropic · closed57.4%80.4%63.2%
Claude Opus 4.8Anthropic · closed59 t/s2.9 min57.9%69.2%88.6%93.6%
Open in the live picker (Q2 / Q4 / Q5 / Q8 toggles) → Compare Quad RTX Pro 6000 Blackwell build (384 GB) with another build → Try other hardware → Submit a benchmark for Quad RTX Pro 6000 Blackwell build (384 GB) ↗

Last updated 2026-07-11